Prenatalsafe® is a non-invasive prenatal screening test which analyses cell-free fetal DNA isolated from a maternal blood sample to provides 6 levels of detailed information of a pregnancy. The test allows the detection of aneuploidies and microdeletion syndromes, from the most common to the rarest, structural alterations in all the chromosomes of the fetus and the presence of mutations related to serious genetic diseases.
Prenatalsafe® is offered by the Eurofins Genoma Group laboratories with an option to choose from six levels of prenatal screening, each with a different level of detail.
is the most technologically advanced non-invasive prenatal screening test currently available
By analysing the cell-free fetal DNA (cfDNA) circulating in the mother's blood, this new non-invasive prenatal test is able to screen fetal karyotype and serious genetic diseases in the fetus. Prenatalsafe® Complete in its "Plus" version also detects the 9 most common microdeletion syndromes.
Detects aneuploidy and structural chromosomal alterations (segmental deletions and duplications) of each chromosome. Moreover, it allows identifying the 9 most common microdeletion syndromes in the fetus under Prenatalsafe® Karyo Plus screening.
| Micro-deletion | Chromosomal Region | Prevalance |
| DiGeorge Synodrome | Deletion 22q11.2 | 1/4,000 |
| Cri du Chat Syndrome | Deletion 5p15.3 | 1/20,000 - 1/50,000 |
| Prader-Willi Syndrome | Deletion 15q11.2 | 1/10,000 - 1/25,000 |
| Angelman Syndrome | Deletion 15q11.2 | 1/12,000 |
| Deletion 1p36 Syndrome | Deletion 1p36 | 1/4,000 - 1/10,000 |
| Wolf-Hirschhorn Syndrome | Deletion 4p16.3 | 1/50,000 |
| Jacobsen Syndrome | Deletion 11q23 | 1/100,000 |
| Langer-Giedion Syndrome | Deletion 8q24 | 1/200,000 |
| Smith-Magenis Syndrome | Deletion 17p11.2 | 1/15,000 - 1/25,000 |
Screens the aneuploidies of chromosomes 21, 18, 13, and the trisomy of chromosomes 9 and 16. The test also detects the presence of the 6 most common microdeletion syndromes.
| Micro-deletion | Chromosomal Region | Prevalance |
| DiGeorge Synodrome | Deletion 22q11.2 | 1/4,000 |
| Cri du Chat Syndrome | Deletion 5p15.3 | 1/20,000 - 1/50,000 |
| Prader-Willi Syndrome | Deletion 15q11.2 | 1/10,000 - 1/25,000 |
| Angelman Syndrome | Deletion 15q11.2 | 1/12,000 |
| Deletion 1p36 Syndrome | Deletion 1p36 | 1/4,000 - 1/10,000 |
| Wolf-Hirschhorn Syndrome | Deletion 4p16.3 | 1/50,000 |
Screens the aneuploidies of chromosomes 21, 18, 13, sex chromosomes (X and Y), and includes the determination of fetal sex (optional).
Screens the aneuploidies of chromosomes 21, 18, 13, and includes the determination of fetal sex (optional).